Researchers from Cancer Research UK Cambridge Research Institute and Institute of Cancer Research (ICR) of this said, the protein called beta or MSMB-microseminoprotein found in low levels in men who are diagnosed with the disease. These proteins also appear to have lower doses in men with other types of cancer more aggressive.
"These proteins are easy to detect because it was found in the urine and potentially will be a very simple test to identify men most at risk of contracting prostate cancer," said Hayley Whitaker of Cambridge Institute who led the study, as quoted from page Reuters Health.
Whitaker stated, approximately five years before the results of this study was published, this test actually been recommended by doctors for use in the clinic. He hopes this research can help doctors and other medical personnel to determine a patient who had aggressive tumors.
Prostate cancer is estimated to kill 258,000 people around the world in 2008 and is the second most common cause of death from cancer in men in the United States. In the UK, approximately 35,000 people diagnosed with prostate cancer and sekira10.000 of whom had died from the disease.
The most effective screening tests available today are usually based on a single biomarker called prostate specific antigen (PSA). However, PSA tests are problematic because they have low specificity resulting in high false positive values and leads to surgical treatment and radiotherapy are not necessary.
A U.S. study released last year found that routine PSA screening has resulted in more than 1 million American men are diagnosed with the tumor, which may not suffer adverse effects from screening it.
A U.S. study released last year found that routine PSA screening has resulted in more than 1 million American men are diagnosed with the tumor, which may not suffer adverse effects from screening it.
"At the current PSA test is the best method we have for detecting prostate cancer, but unfortunately have significant limitations. So, there is an urgent need to discover new biomarkers, such as MSMB which can be used in screening and diagnosis, "said Rosalind Eeles of the ICR and The Royal Marsden Hospital who also worked on the study.
Protein that regulates cell death of prostate-produced by normal prostate cells. The researchers took tissue and urine samples of about 350 people, both suffering from or who do not get prostate cancer to test the level MSMB.
The results, published in the journal Public Library of Science (PLoS) ONE, shows that MSMB found at significantly lower levels in urine of humans who were diagnosed with prostate cancer than those without the disease. They also point to the fact that men with aggressive tumors also tend to have high levels of protein in their urine.
Commenting on this study, Kate Holmes from the Prostate Cancer Charity in England hoped, (the scientists) could provide evidence on this issue which is very valuable in the future.
"Given the limitations resulting from the PSA blood test, discovered a technique that more accurately diagnose prostate cancer is the core research on this disease," he said.
"And accurate urine test that can be relied upon for prostate cancer will become an invaluable tool if it proves successful in large scale," said Holmes.
The prostate gland itself is contained under the male bladder. The main function of the prostate is to produce fluid which protects and deliver sperm. The prostate often enlarges gradually after the age of 50 years. At the age of 70 years, 80 percent of men have an enlarged prostate. Many elderly men who have trouble urinating due to prostate enlargement (non cancer).
In some men, this enlargement was followed by the growth of cancer. Meanwhile, prostate cancer occurs when prostate cells grow faster than normal conditions to form lumps or tumors that have a malignancy. This cancer is most common in men, particularly those aged over 65 years.
Prostate cancer is rarely attack men under 45 years, except when any of your family who are suffering. The exact cause is unknown, but there are some things that can increase a person's risk for prostate cancer are age and family history. Hormones, diet high in fat, and toxins, is also mentioned as risk factors for prostate cancer although the relation is not clear.
While in Asia is still relatively little sufferer, data from 13 state university medical school in Indonesia shows prostate cancer is high. Malignant disease can not be ignored because it has killed around 10,000 men each case. The disease is usually curable if detected at an early stage.
Unfortunately, this cancer often grows silently in the prostate gland without any symptoms to spread to the bone and surrounding tissue. That is why it is important for adult men to undergo a digital rectal test that allows doctors found a lump or enlargement of the prostate. In addition, there are also prostate-specific antigen blood test, blood test to detect which type of protein that comes out when there is a tumor of the prostate.
If the doctor finds cancer, the treatment will depend on several factors, including tumor size, growth rate, and whether the disease has spread beyond the prostate. Treatment to include radiation, removal of the prostate through surgery, and hormone therapy to lower testosterone levels.
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